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Wednesday, June 06, 2012


  • Epicatechin has previously been suggested to rapidly reverse alloxan diabetes in rats. we have assessed the therapeutic value of the compound in two further animal models of insulin-dependent diabetes mellitus, namely streptozotocin-diabetic rats and the spontaneously diabetic BB/E rat.
  • There was no indication of areversal of established diabetes in either the streptozotocin-diabetic or the spontaneously diabetic BB/E rats.
  • The results indicate that much of the increase in the level of (-)-catechin observed during various processing steps may be the result of heat-related epimerization from epicatechin.
  • Epicatechin effects would be beneficial in supporting the management of secondary complications of diabetes. Polyphenols were shown to be useful in the long term preservation of rat pancreatic islets in vitro under physiological condition.

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